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Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis.

Artikel i vetenskaplig tidskrift
Författare Ola Hjelmgren
Karl Gellerman
Josefin Kjelldahl
Per Lindahl
Göran Bergström
Publicerad i PloS one
Volym 11
Nummer/häfte 12
Sidor e0166918
ISSN 1932-6203
Publiceringsår 2016
Publicerad vid Wallenberglaboratoriet
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor e0166918
Språk en
Länkar dx.doi.org/10.1371/journal.pone.016...
www.ncbi.nlm.nih.gov/entrez/query.f...
https://gup.ub.gu.se/file/206878
Ämneskategorier Radiologi och bildbehandling, Invärtesmedicin, Medicinska grundvetenskaper

Sammanfattning

Vascularization of atherosclerotic plaques has been linked to plaque vulnerability. The aim of this study was to test if the vascularization was increased in upstream regions of early atherosclerotic carotid plaques and also to test if the same pattern of vascularization was seen in complicated, symptomatic plaques.We enrolled 45 subjects with early atherosclerotic lesions for contrast enhanced ultrasound and evaluated the percentage of plaque area in a longitudinal ultrasound section which contained contrast agent. Contrast-agent uptake was evaluated in both the upstream and downstream regions of the plaque. We also collected carotid endarterectomy specimens from 56 subjects and upstream and downstream regions were localized using magnetic resonance angiography and analyzed using histopathology and immunohistochemistry.Vascularization was increased in the upstream regions of early carotid plaques compared with downstream regions (30% vs. 23%, p = 0.033). Vascularization was also increased in the upstream regions of advanced atherosclerotic lesions compared with downstream regions (4.6 vs. 1.4 vessels/mm2, p = 0.001) and was associated with intra-plaque hemorrhage and inflammation.Vascularization is increased in the upstream regions of both early and advanced plaques and is in advanced lesions mainly driven by inflammation.

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