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Vitamin A and sudden infant death syndrome in Scandinavia 1992-1995.

Artikel i vetenskaplig tidskrift
Författare Bernt Alm
Göran Wennergren
Gunnar Norvenius
R Skjaerven
H Lagercrantz
K Helweg-Larsen
L M Irgens
Publicerad i Acta paediatrica (Oslo, Norway : 1992)
Volym 92
Nummer/häfte 2
Sidor 162-4
ISSN 0803-5253
Publiceringsår 2003
Publicerad vid Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 162-4
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Case-Control Studies, Cod Liver Oil, administration & dosage, standards, therapeutic use, Denmark, epidemiology, Dietary Supplements, standards, statistics & numerical data, Humans, Infant, Infant, Newborn, Norway, epidemiology, Retrospective Studies, Sudden Infant Death, etiology, prevention & control, Sweden, epidemiology, Time Factors, Vitamin A, administration & dosage, standards, therapeutic use, Vitamin A Deficiency, complications, mortality, prevention & control
Ämneskategorier Farmakologi, Folkhälsovetenskap, Epidemiologi, Pediatrik

Sammanfattning

To assess the effect of vitamin supplementation on the risk of sudden infant death syndrome (SIDS).The analyses are based on data from the Nordic Epidemiological SIDS Study, a case-control study in which parents of SIDS victims in the Scandinavian countries were invited to participate together with parents of four matched controls between 1 September 1992 and 31 August 1995. The odds ratios presented are computed by conditional logistic regression analysis.The crude odds ratio in Scandinavia for not giving vitamin substitution was 2.8 (95% CI (1.9, 4.3)). This effect was statistically significant in Norway and Sweden, which use A and D vitamin supplementation, but not in Denmark, where only vitamin D supplementation is given. The odds ratios remained significant in Sweden when an adjustment was made for confounding factors (OR 28.4, 95% CI (4.7, 171.3)).We found an association between increased risk of sudden infant death syndrome and infants not being given vitamin supplementation during their first year of life. This was highly significant in Sweden, and the effect is possibly connected with vitamin A deficiency. This effect persisted when an adjustment was made for potential confounders, includingsocioeconomic factors.

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