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Increase of the soluble IL-4 receptor (IL-4sR) and positive correlation between IL-4sR and IgE in nasal fluids from school children with allergic rhinitis.

Artikel i vetenskaplig tidskrift
Författare Mikael Benson
Inga-Lisa Strannegård
Göran Wennergren
Örjan Strannegård
Publicerad i Allergy and asthma proceedings
Volym 21
Nummer/häfte 2
Sidor 89-95
ISSN 1088-5412
Publiceringsår 2000
Publicerad vid Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi
Sidor 89-95
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin E, analysis, Inflammation Mediators, analysis, Male, Nasal Lavage Fluid, immunology, Probability, Prognosis, Prospective Studies, Receptors, Interleukin-4, analysis, Reference Values, Rhinitis, Allergic, Perennial, immunology, Sensitivity and Specificity, Tumor Necrosis Factor-alpha, analysis
Ämneskategorier Allergologi, Lungmedicin och allergi, Pediatrik

Sammanfattning

Soluble cytokine receptors (SCR) can either act as inhibitors, by competitively inhibiting cytokines from binding to their membrane-bound receptors, or as enhancers, by serving as cytokine carriers. We have previously found that the levels of the Th2 cytokines interleukin (IL)-4, IL-5, IL-6, and IL-10 were positively correlated to eosinophils and IgE in nasal fluids from 60 children with seasonal allergic rhinitis. In this study, nasal fluids were reexamined to analyze IL-4sR, IL-6sR, IL-1 beta, TNF-alpha, IL-1sR2, TNF-sR1, and TNFsR2 in relation to eosinophils, neutrophils, ECP, and IgE. In allergic patients IL-4sR increased significantly during the pollen season, and weak, but positive correlations with IgE and eosinophils were found (r = 0.45, P < 0.001 and r = 0.4, P < 0.001 respectively). By contrast, none of the other SCR showed increases or correlations with IgE. However, positive correlations between IL1 beta, TNF-alpha, IL-6sR, IL-1sR2, TNF-sR1, TNF-sR2, and either neutrophils or ECP were found. Also, in healthy controls, these cytokines and their receptors were positively correlated to neutrophils or ECP. Thus, increased levels of the soluble IL-4 receptor, as well as IgE, were specifically associated with allergic rhinitis, whereas all other SCR correlated with either inflammatory cells or their products, in both allergic and healthy subjects. These results may suggest that SCR in vivo act as cytokine enhancers, rather than inhibitors.

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