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Association between APOE Genotype and Change in Physical Function in a Population-Based Swedish Cohort of Older Individuals Followed Over Four Years

Artikel i vetenskaplig tidskrift
Författare Ingmar Skoog
Helena M Hörder
Kerstin Frändin
Lena Johansson
Svante Östling
Kaj Blennow
Henrik Zetterberg
Anna Zettergren
Publicerad i Frontiers in Aging Neuroscience
Volym 8
Sidor Article number: 225
ISSN 1663-4365
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor Article number: 225
Språk en
Länkar dx.doi.org/10.3389/fnagi.2016.00225
Ämnesord physical function, grip strength, gait speed, APOE epsilon 4 allele, dementia, apolipoprotein-e polymorphism, alzheimers-disease, cognitive decline, grip strength, allele, adults, risk, women, performance, prevalence, Geriatrics & Gerontology, Neurosciences & Neurology
Ämneskategorier Klinisk medicin

Sammanfattning

The association between decline in physical function and age-related conditions, such as reduced cognitive performance and vascular disease, may be explained by genetic influence on shared biological pathways of importance for aging. The apolipoprotein F (APOE) gene is well-known for its association with Alzheimer's disease, but has also been related to other disorders of importance for aging. The aim of this study was to investigate possible associations between APOE allele status and physical function in a population-based longitudinal study of older individuals. In 2005, at the age of 75, 622 individuals underwent neuropsychiatric and physical examinations, including tests of physical function, and APOE-genotyping. Follow-up examinations were performed at age 79. A significantly larger decline in grip strength (p = 0.015) between age 75 and 79 was found when comparing APOE epsilon 4 allele carriers with non carriers [10.3 (+/- 10.8) kg versus 7.8 (+/- 10.1) kg]. No association was seen with decline in gait speed, chair-stand, or balance. The association with grip strength remained after correction for cognitive and educational level, depression, cardiovascular disease, stroke, and BMI.

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