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Rigorous Tests of Gene-Environment Interactions in a Lab Study of the Oxytocin Receptor Gene (OXTR), Alcohol Exposure, and Aggression

Artikel i vetenskaplig tidskrift
Författare D. LoParo
Ada Johansson
H. Walum
Lars Westberg
P. Santtila
I. Waldman
Publicerad i American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Volym 171
Nummer/häfte 5
Sidor 589-602
ISSN 1552-4841
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 589-602
Språk en
Länkar dx.doi.org/10.1002/ajmg.b.32359
Ämnesord oxytocin, aggression, alcohol, laboratory aggression, reactive aggression, conduct disorder, social-behavior, trait anger, male rats, humans, provocation, vasopressin, attention, Genetics & Heredity, Psychiatry
Ämneskategorier Farmakologi och toxikologi, Neurovetenskaper, Medicinsk genetik

Sammanfattning

Naturalistic studies of gene-environment interactions (G X E) have been plagued by several limitations, including difficulty isolating specific environmental risk factors from other correlated aspects of the environment, gene-environment correlation (r(GE)), and the use of a single genetic variant to represent the influence of a gene. We present results from 235 Finnish young men in two lab studies of aggression and alcohol challenge that attempt to redress these limitations of the extant G X E literature. Specifically, we use a latent variable modeling approach in an attempt to more fully account for genetic variation across the oxytocin receptor gene (OXTR) and to robustly test its main effects on aggression and its interaction with alcohol exposure. We also modeled aggression as a latent variable comprising various indices, including the average and maximum levels of aggression, the earliest trial on which aggression was expressed, and the proportion of trials on which the minimum and maximum levels of aggression were expressed. The best fitting model for the genetic variation across OXTR included six factors derived from an exploratory factor analysis, roughly corresponding to six haplotype blocks. Aggression levels were higher on trials in which participants were administered alcohol, won, or were provoked. There was a significant main effect of OXTR on aggression across studies after controlling for covariates. The interaction of OXTR and alcohol was also significant across studies, such that OXTR had stronger effects on aggression in the alcohol administration condition. (C) 2015 Wiley Periodicals, Inc.

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