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On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited

Artikel i vetenskaplig tidskrift
Författare D. Williams
Mikael Nilsson
Publicerad i European Thyroid Journal
Volym 5
Nummer/häfte 2
Sidor 79-93
ISSN 2235-0640
Publiceringsår 2016
Publicerad vid Sahlgrenska Cancer Center
Institutionen för biomedicin
Sidor 79-93
Språk en
Länkar dx.doi.org/10.1159/000447333
Ämnesord Endoderm, Mixed medullary-follicular carcinoma, Neural crest, Neuroendocrine tumours, Thyroid C, NEURAL CREST ORIGIN, ENDOCRINE NEOPLASIA TYPE-2, CALCITONIN-PRODUCING, CELLS, UNILATERAL RENAL AGENESIS, OF-THE-LITERATURE, MIXED MEDULLARY, RET PROTOONCOGENE, ULTIMOBRANCHIAL GLANDS, FOLLICULAR CARCINOMA, TRANSGENIC MICE
Ämneskategorier Cell- och molekylärbiologi, Tumörimmunologi

Sammanfattning

We will highlight and put into perspective new lineage tracing data from genetic studies in mice indicating that the genuine progenitors to C cells arise in the endoderm germ layer. This overturns the current concept of a neural crest origin of thyroid C cells referred to in every textbook and dedicated paper to this very day. As will become apparent, except for a single experiment, the neural crest theory has little or no support when the evolution and development of calcitonin-producing cells in the entire chordate family are considered. Instead, a unifying origin of all cells of the ultimobranchial bodies reopens questions on the histogenesis of certain thyroid pathologies previously difficult to explain. On this aspect, medullary thyroid cancer shows a stronger connection to gut neuroendocrine tumours than previously recognized. It is envisaged that novel factors implicated in C cell-derived tumour growth and progression will be discovered as the mechanisms that regulate lineage expansion of embryonic C cell precursors from pharyngeal endoderm are uncovered. We will not discuss why C cells go to the bother of burying themselves in the thyroid - this remains a mystery. (C) 2016 European Thyroid Association Published by S. Karger AG, Basel

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