Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

A worldwide survey of chr… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

Artikel i vetenskaplig tidskrift
Författare A. H. Morice
A. D. Jakes
S. Faruqi
S. S. Birring
L. McGarvey
B. Canning
J. A. Smith
S. M. Parker
K. F. Chung
K. Lai
I. D. Pavord
J. van den Berg
W. J. Song
Eva Millqvist
M. J. Farrell
S. B. Mazzone
P. Dicpinigaitis
Registry Chronic Cough
Publicerad i European Respiratory Journal
Volym 44
Nummer/häfte 5
Sidor 1149-1155
ISSN 0903-1936
Publiceringsår 2014
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 1149-1155
Språk en
Länkar dx.doi.org/10.1183/09031936.0021781...
Ämnesord adolescent; adult; age distribution; aged; child; chronic disease; coughing; female; health; human; infant; inhalational drug administration; male; middle aged; newborn; normal human; nuclear magnetic resonance imaging; pathophysiology; preschool child; reflex; register; retrospective study; sex difference; sex ratio; somatosensory cortex; very elderly; young adult
Ämneskategorier Invärtesmedicin, Neurologi, Radiologi och bildbehandling

Sammanfattning

Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have reviewed the age and sex of unselected referrals to 11 cough clinics. To investigate the cause of any observed sex dimorphism, functional magnetic resonance imaging of putative cough centres was analysed in normal volunteers. The demographic profile of consecutive patients presenting with chronic cough was evaluated. Cough challenge with capsaicin was undertaken in normal volunteers to construct a concentration-response curve. Subsequent functional magnetic resonance imaging during repeated inhalation of sub-tussive concentrations of capsaicin observed areas of activation within the brain and differences in the sexes identified. Of the 10,032 patients presenting with chronic cough, two-thirds (6591) were female (mean age 55 years). The patient profile was largely uniform across centres. The most common age for presentation was 60-69 years. The maximum tolerable dose of inhaled capsaicin was lower in females; however, a significantly greater activation of the somatosensory cortex was observed. Patients presenting with chronic cough from diverse racial and geographic backgrounds have a strikingly homogeneous demographic profile, suggesting a distinct clinical entity. The preponderance of females may be explained by sex-related differences in the central processing of cough sensation. ©ERS 2014.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?