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One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation

Artikel i vetenskaplig tidskrift
Författare Mats Brännström
Hans Bokström
Pernilla Dahm-Kähler
César Diaz-Garcia
Jana Ekberg
Anders Enskog
Henrik Hagberg
Liza Johannesson
Niclas Kvarnström
Johan Mölne
Michael Olausson
J. I. Olofsson
K. Rodriguez-Wallberg
Publicerad i Fertility and Sterility
Volym 106
Nummer/häfte 2
Sidor 261-266
ISSN 0015-0282
Publiceringsår 2016
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för kirurgi
Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård
Institutionen för biomedicin, avdelningen för patologi
Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Sidor 261-266
Språk en
Länkar dx.doi.org/10.1016/j.fertnstert.201...
Ämnesord Human, infertility, pregnancy, transplantation, uterus, VASCULAR ANASTOMOSIS, AUTOTRANSPLANTATION, LIVEBIRTH, PREGNANCY, TRIAL, MOUSE
Ämneskategorier Transplantationskirurgi, Obstetrik och gynekologi

Sammanfattning

Objective: To determine whether a uterus from the mother of a woman with absolute uterine factor infertility can be transplanted to daughter and carry a pregnancy with delivery of a healthy child. Patient(s): Twenty eight-year-old woman with uterine agenesis, her male partner, and her 50-year-old mother. Intervention(s): In vitro fertilization with embryo cryopreservation before live donor uterus transplantation (UTx). Induction immunosuppression. Embryo transfer 12 months after UTx, pregnancy controls, delivery, and hysterectomy. Main Outcome Measure(s): Results of IVF-ET, parameters of pregnancy/birth, and surgical data of transplantation/cesarean section/hysterectomy. Result(s): Two IVF cycles before UTx resulted in 10 cryopreserved embryos. Donor surgery included hysterectomy with vascular pedicles of uterine vessels and proximal vessels up to and including parts of internal iliacs. Recipient surgery was by bilateral vascular connections to external iliacs, vaginal-vaginal anastomosis, and uterine fixation. Pregnancy occurred at the first single ET, and the pregnancy proceeded uneventfully until gestational week 34, when the patient developed cholestasis with intense pruritus. Cesarean section was performed at 34+6, with delivery of a healthy boy (weight 2,335 g). Hysterectomy was performed 3.5 months after delivery. The weight of the healthy child at 12 months was 9.3 kg. Grandmother (uterus donor) and mother are in good health 3 years after UTx. Conclusion(s): This is the first report of a live birth after mother-to-daughter UTx, and it also represents the second birth ever after human UTx. (C) 2016 by American Society for Reproductive Medicine.

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