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Plasma Brain-Derived Neurotrophic Factor and Psychopathology in Attempted Suicide

Artikel i vetenskaplig tidskrift
Författare L. Ambrus
C. Sunnqvist
Rolf Ekman
L. Traskman-Bendz
A. Westrin
Publicerad i Neuropsychobiology
Volym 73
Nummer/häfte 4
Sidor 241-248
ISSN 0302-282X
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 241-248
Språk en
Länkar dx.doi.org/10.1159/000446286
Ämnesord Brain-derived neurotrophic factor, Psychopathology, Suicide, personality-traits, bdnf levels, factor expression, major depression, withdrawal, symptoms, behavior, scale, vulnerability, association, Neurosciences & Neurology, Psychiatry, Psychology
Ämneskategorier Klinisk medicin

Sammanfattning

Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality dimension Solidity but not with the other personality dimensions or with clinical symptoms. Conclusion: BDNF plays an important role in the regulation of neuroplasticity and neurogenesis in humans. Our results indicate that lower BDNF concentrations are associated with higher levels of impulsiveness and changeability (low scores on the Solidity scale). Furthermore, low plasma BDNF levels may be proposed as a trait marker rather than a state marker for attempted suicide. (C) 2016 S. Karger AG, Basel

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