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Food-induced changes of lipids in rat neuronal tissue visualized by ToF-SIMS imaging

Artikel i vetenskaplig tidskrift
Författare M. D. Pour
Eva Jennische
Stefan Lange
Andrew G Ewing
Per Malmberg
Publicerad i Scientific Reports
Volym 6
ISSN 2045-2322
Publiceringsår 2016
Publicerad vid Institutionen för biomedicin
Institutionen för kemi och molekylärbiologi
Språk en
Länkar dx.doi.org/10.1038/srep32797
https://gup.ub.gu.se/file/201098
Ämnesord ion mass-spectrometry, antisecretory factor, alzheimers-disease, menieres-disease, cell-membranes, brain-tissue, cholesterol, phosphatidylethanolamine, localization, protein, Science & Technology - Other Topics
Ämneskategorier Kemi, Biologiska vetenskaper

Sammanfattning

Time of flight secondary ion mass spectrometry (ToF-SIMS) was used to image the lipid localization in brain tissue sections from rats fed specially processed cereals (SPC). An IonTof 5 instrument equipped with a Bi cluster ion gun was used to analyze the tissue sections. Data from 15 brain samples from control and cereal-fed rats were recorded and exported to principal components analysis (PCA). The data clearly show changes of certain lipids in the brain following cereal feeding. PCA score plots show a good separation in lipid distribution between the control and the SPC-fed group. The loadings plot reveal that the groups separated mainly due to changes in cholesterol, vitamin E and c18:2, c16:0 fatty acid distribution as well as some short chain monocarboxylic fatty acid compositions. These insights relate to the working mechanism of SPC as a dietary supplement. SPC is thought to activate antisecretory factor (AF), an endogenous protein with regulatory function for inflammation and fluid secretion. These data provide insights into lipid content in brain following SPC feeding and suggest a relation to activating AF.

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