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The renin–angiotensin system in Barrett’s esophagus

Artikel i vetenskaplig tidskrift
Författare Svein-Olav Bratlie
Anders Edebo
Anna Casselbrant
Herbert F Helander
Lars Fändriks
Publicerad i Scandinavian Journal of Gastroenterology
Volym 51
Nummer/häfte 9978
Sidor 1037-1042
ISSN 0036-5521
Publiceringsår 2016
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning
Sidor 1037-1042
Språk en
Länkar dx.doi.org/10.1080/00365521.2016.11...
https://gup.ub.gu.se/file/197103
Ämnesord Barrett’s esophagus; biomarkers; endoscopy; esophageal adenocarcinoma; renin–angiotensin receptor
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

ABSTRACT Objective: Barrett’s esophagus (BE) is a risk factor for esophageal adenocarcinoma. In addition to its classical endocrine character known for hemodynamic regulation, the renin–angiotensin system (RAS) can be associated with inflammation, wound healing, and cancer. The aim of this study was to explore a potential expression of the RAS in BE, with or without the presence of dysplasia. Material and methods: Biopsy material was prepared for western blotting and immunohistochemistry. Non-BE patients (controls) were compared with BE patients regarding RAS in the squamous epithelium. In the columnar BE mucosa, RAS expression was studied in patients with and without dysplasia. Key components of the ‘classical’ RAS were assessed: the angiotensin-converting enzyme (ACE) and the angiotensin II subtype 1 and 2 receptors (AT1R and AT2R). Results: The presence of RAS factors was confirmed in the esophageal mucosa of both control and BE patients. ACE protein expression was 48% lower (p1⁄40.001) whereas AT1R was 45% higher (p1⁄40.039) in the squamous epithelium of BE patients compared to epithelia from non-BE controls. In the meta- plastic intestinal-like epithelium, AT1R expression was 37% higher in BE patients with confirmed dyspla- sia than in patients without dysplasia (p 1⁄4 0.009). Immunohistochemistry showed an altered distribution of RAS proteins in BE patients with dysplasia. Conclusions: The differential RAS expression observed may prove to be useful as a biomarker or a pharmaceutical target.

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