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L-arginine promotes gut hormone release and reduces food intake in rodents

Artikel i vetenskaplig tidskrift
Författare A. Alamshah
A. K. McGavigan
E. Spreckley
J. S. Kinsey-Jones
A. Amin
I. R. Tough
H. C. O'Hara
A. Moolla
K. Banks
R. France
G. Hyberg
M. Norton
W. Cheong
Anders Lehmann
S. R. Bloom
H. M. Cox
K. G. Murphy
Publicerad i Diabetes Obesity & Metabolism
Volym 18
Nummer/häfte 5
Sidor 508-518
ISSN 1462-8902
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 508-518
Språk en
Länkar dx.doi.org/10.1111/dom.12644
Ämnesord animal pharmacology, body composition, energy regulation, GLP-1, obesity therapy, amino acid receptor, peptide-yy, nitric-oxide, body-weight, central, mechanisms, insulin-secretion, stimulates glp-1, gprc6a receptor, vagal, afferents, neuropeptide-y, Endocrinology & Metabolism
Ämneskategorier Endokrinologi

Sammanfattning

Aims: To investigate the anorectic effect of L-arginine (L-Arg) in rodents. Methods: We investigated the effects of L-Arg on food intake, and the role of the anorectic gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), the G-protein-coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents. Results: Oral gavage of L-Arg reduced food intake in rodents, and chronically reduced cumulative food intake in diet-induced obese mice. Lack of the GPRC6A in mice and subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. L-Arg stimulated GLP-1 and PYY release in vitro and in vivo. Pharmacological blockade of GLP-1 and PYY receptors did not influence the anorectic effect of L-Arg. L-Arg-mediated PYY release modulated net ion transport across the gut mucosa. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of L-Arg suppressed food intake in rats. Conclusions: L-Arg reduced food intake and stimulated gut hormone release in rodents. The anorectic effect of L-Arg is unlikely to be mediated by GLP-1 and PYY, does not require GPRC6A signalling and is not mediated via the vagus. I.c.v. and i.p. administration of L-Arg suppressed food intake in rats, suggesting that L-Arg may act on the brain to influence food intake. Further work is required to determine the mechanisms by which L-Arg suppresses food intake and its utility in the treatment of obesity.

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