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Cataract after allogeneic hematopoietic stem cell transplantation in childhood

Artikel i vetenskaplig tidskrift
Författare Kristina Teär Fahnehjelm
A. L. Tornquist
M. Olsson
Ingrid Bäckström
Marita Andersson Grönlund
J. Winiarski
Publicerad i Acta Paediatrica
Volym 105
Nummer/häfte 1
Sidor 82-89
ISSN 0803-5253
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 82-89
Språk en
Länkar dx.doi.org/10.1111/apa.13173
Ämnesord Cataract, Hematopoietic stem cell transplantation, Total body irradiation, Visual outcome, BONE-MARROW-TRANSPLANTATION, TOTAL-BODY IRRADIATION, VERSUS-HOST-DISEASE, QUALITY-OF-LIFE, OCULAR COMPLICATIONS, CHILDREN, SURVIVORS
Ämneskategorier Pediatrik, Oftalmologi

Sammanfattning

AimThe aim of this study was to study long-term visual outcome and cataract development in children and adolescents after hematopoietic stem cell transplantation (HSCT) in childhood. MethodsBest corrected visual acuity (BCVA), refraction and lens status were examined in a prospective study of 139 children and adolescents. ResultsIn total, 139 patients (58 female), median age 6.6years at HSCT (range 0.4-17.5years), were followed up for a median of 8.0years (1-19.4years). Median BCVA in the better eye was 1.0 decimal. Altogether 19 of 131 patients developed cataract requiring surgery, while 46 developed less prominent lens opacities and 66 had clear lenses at time of latest follow-up. Patients conditioned with total body irradiation had a higher risk of developing lens opacities or cataract (p<0.0001) as did patients with malignant disease, irrespective of irradiation treatment (p<0.0001). Cumulative analysis showed that 50% of all patients had developed lens opacities/cataract after 10.2years. Patients who ultimately needed cataract surgery developed cataract earlier than others (p=0.006). ConclusionLens opacities or cataract were more common in children or adolescents with malignant disease and after conditioning with irradiation. Regular ophthalmological follow-up is important after HSCT for early intervention to avoid amblyopia.

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