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Association between polymorphisms in NOS3 and KCNH2 and social memory

Artikel i vetenskaplig tidskrift
Författare Susanne Henningsson
Anna Zettergren
Daniel Hovey
Lina Jonsson
J. Svärd
D. S. Cortes
Jonas Melke
N. C. Ebner
P. Laukka
H. Fischer
Lars Westberg
Publicerad i Frontiers in Neuroscience
Volym 9
Nummer/häfte OCT
Sidor 393
ISSN 1662-4548
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 393
Språk en
Länkar dx.doi.org/10.3389/fnins.2015.00393
Ämnesord Face recognition, KCNH2, Memory, Nitric oxide, NOS3, Social
Ämneskategorier Neurovetenskaper

Sammanfattning

Social memory, including the ability to recognize faces and voices, is essential for social relationships. It has a large heritable component, but the knowledge about the contributing genes is sparse. The genetic variation underlying inter-individual differences in social memory was investigated in an exploratory sample (n = 55), genotyped with a chip comprising approximately 200,000 single nucleotide polymorphisms (SNPs), and in a validation sample (n = 582), where 30 SNPs were targeted. In the exploratory study face identity recognition was measured. The validation study also measured vocal sound recognition, as well as recognition of faces and vocal sounds combined (multimodal condition). In the exploratory study, the 30 SNPs that were associated with face recognition at puncorrected < 0.001 and located in genes, were chosen for further study. In the validation study two of these SNPs showed significant associations with recognition of faces, vocal sounds, and multimodal stimuli: rs1800779 in the gene encoding nitric oxide synthase 3 (NOS3) and rs3807370 in the gene encoding the voltage-gated channel, subfamily H, member 2 (KCNH2), in strong linkage disequilibrium with each other. The uncommon alleles were associated with superior performance, and the effects were present for men only (p < 0.0002). The exploratory study also showed a weaker but significant association with (non-emotional) word recognition, an effect that was independent of the effect on face recognition. This study demonstrates evidence for an association between NOS3 and KCNH2 SNPs and social memory. © 2015 Henningsson, Zettergren, Hovey, Jonsson, Svärd, Cortes, Melke, Ebner, Laukka, Fischer and Westberg.

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