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A follow-up study of vaccine-induced aluminium contact allergy in a population of 76 000 children vaccinated with aluminium-adsorbed vaccine: differences in patch test reaction between aluminium hexahydrate 2% in petrolatum and metallic aluminium

Konferensbidrag (offentliggjort, men ej förlagsutgivet)
Författare Anette Gente-Lidholm
Annica Inerot
Elisabet Bergfors
Ulla Blomgren
Birger Trollfors
Martin Gillstedt
Publicerad i Br J Dermatol. 2015 Jul;173 Suppl 1:1-208
Publiceringsår 2015
Publicerad vid
Språk en
Ämnesord aluminium, contact allergy, vaccine
Ämneskategorier Dermatologi och venereologi, Klinisk medicin

Sammanfattning

This is a follow-up study of children with aluminium contact dermatitis caused by aluminium-adsorbed vaccines, given during the 1990s in Sweden to more than 76 000 children, from a single producer, Statens Serum Institute, Denmark. Our aim were to study the patch test reactions of two different forms of aluminium – metallic aluminium and a salt – in children with vaccine-induced aluminium contact dermatitis. Contact dermatitis was confirmed by a patch test, on the upper part of the back, using two different forms of aluminium: metallic aluminium (empty Finn Chamber®) and an aluminium salt (aluminium chloride hexahydrate 2% in petrolatum). The first tests (study I) were performed during the period 1998–2002 and the second tests were repeated exactly in the same way in the follow-up study in 2007–2008 (study II). In study I, of 455 tested children, 77% had a positive patch test result. Study II comprised 241 children who tested positive in study I. In this second test 186 children (77%) had negative tests and 55 had positive test results. Of those 55 children, 40 (75%) had positive patch test results to the aluminium salt only, 14 (25%) were positive to both forms and only one was exclusively positive to the metallic aluminium. In conclusion, aluminium salt is more allergenic in the patch test system than aluminium in the metallic form. The results indicate that it is not sufficient to use only metallic aluminium when patch testing for aluminium allergy.

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