Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän

Effects of sex and gonade… - Göteborgs universitet Till startsida
Till innehåll Läs mer om hur kakor används på gu.se

Effects of sex and gonadectomy on social investigation and social recognition in mice

Artikel i vetenskaplig tidskrift
Författare Sara Karlsson
Kaltrina Haziri
Evelyn Hansson
Petronella Kettunen
Lars Westberg
Publicerad i Bmc Neuroscience
Volym 16
ISSN 1471-2202
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Språk en
Länkar dx.doi.org/10.1186/s12868-015-0221-...
Ämnesord Social behaviour, Memory, Three-chambered apparatus test, Sex differences, Estrogens, Androgens, ESTROGEN-RECEPTOR-ALPHA, ANDROGEN RECEPTOR, FEMALE RATS, LABORATORY, RATS, OLFACTORY CUES, HORMONES, GENE, TESTOSTERONE, BEHAVIORS, MEMORY
Ämneskategorier Farmakologi


Background: An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but information about the factors that underpin these differences is sparse. Our aim was therefore to investigate if sociability and social recognition differ between female and male mice, and if so, to what extent gonadal hormones may be involved. Intact and gona-dectomised male and female mice were assessed for sociability and social recognition using the three-chambered sociability paradigm, as well as the social discrimination test. Furthermore, we conducted a novel object recognition test, a locomotor activity test and an odour habituation/dishabituation test. Results: The present study showed that the ability to recognise other individuals is intact in males with and without gonads, as well as in intact females, whereas it is hampered in gonadectomised females. Additionally, intact male mice displayed more persistent investigatory behaviour compared to the other groups, although the intact females showed elevated basal locomotor activity. In addition, all groups had intact object memory and habituated to odours. Conclusions: Our results suggest that intact male mice investigate conspecifics more than females do, and these differences seem to depend upon circulating hormones released from the testis. As these results seem to contrast what is known from human studies, they should be taken into consideration when using the three-chambered apparatus, and similar paradigms as animal models of social deficits in e.g. autism. Other behavioural tests, and animal models, may be more suitable for translational studies between patients and experimental animals.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?