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Epigenetic changes induced by exercise

Artikel i vetenskaplig tidskrift
Författare Trevor Archer
Publicerad i Journal of Reward Deficiency Syndrome
Volym 1
Nummer/häfte 2
ISSN 2475-1405
Publiceringsår 2015
Publicerad vid Psykologiska institutionen
Språk en
Länkar doi.org/10.17756/jrds.2015-011
Ämnesord Exercise, nutrition, DNA methylation, development, epigenetics
Ämneskategorier Psykologi

Sammanfattning

Physical exercise offers an epigenetic propensity that holds benefits with several health domains, particularly for children and adolescents. Yet, it is only recently that that regular exercise has begun to be construed as a positive epigenetic mechanism to modify the genome-wide DNA methylation pattern in humans. Epigenetics is emerging a science that examines processes-beyond DNA sequence alteration-producing heritable characteristics with exercise regimes, with or without dietary restrictions, as essential epigenetic interventions. Nevertheless, Exercise and nutrition are synergistic in mitigating disorder states with exercise releasing exosomes that contain miRNAs. Nutrition/vitamins B6 and B12 regulate the metabolism of homocysteine, an epigenetic byproduct of DNA/RNA/protein methylation. This type of development ushers in, amongst other aspects, the fact that DNA methylation induces modification of gene expression without causing any the nucleotide sequence. In the context of health problems associated with obesity, Genotyping on a Romanian sample of 53 subjects (30 obese, 23 normal) showedthat FTO rs9939609 polymorphism has been identified as a common gene variant in the Romanian Caucasian cohort, suggesting a high association with all the parameters of obesity and obesity comorbidities. It was found that an adherence to a Mediterranean diet was beneficial for participants with genetic predisposition for obesity if maintained over a long interval and combined with sustained physical exercise.

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