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Joint modeling of longitudinal change and survival

Artikel i vetenskaplig tidskrift
Författare G.M. Terrera
A.M. Piccinin
Boo Johansson
F. Matthews
S.M. Hofer
Publicerad i GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry
Volym 24
Nummer/häfte 4
Sidor 177-185
ISSN 1662-9647
Publiceringsår 2011
Publicerad vid Psykologiska institutionen
Sidor 177-185
Språk en
Länkar dx.doi.org/10.1024/1662-9647/a00004...
Ämnesord aging, cognitive decline, joint longitudinal survival models, memory scores
Ämneskategorier Psykologi

Sammanfattning

Joint longitudinal-survival models are useful when repeated measures and event time data are available and possibly associated. The application of this joint model in aging research is relatively rare, albeit particularly useful, when there is the potential for nonrandom dropout. In this article we illustrate the method and discuss some issues that may arise when fitting joint models of this type. Using prose recall scores from the Swedish OCTO-Twin Longitudinal Study of Aging, we fitted a joint longitudinal-survival model to investigate the association between risk of mortality and individual differences in rates of change in memory. A model describing change in memory scores as following an accelerating decline trajectory and a Weibull survival model was identified as the best fitting. This model adjusted for random effects representing individual variation in initial memory performance and change in rate of decline as linking terms between the longitudinal and survival models. Memory performance and change in rate of memory decline were significant predictors of proximity to death. Joint longitudinal-survival models permit researchers to gain a better understanding of the association between change functions and risk of particular events, such as disease diagnosis or death. Careful consideration of computational issues may be required because of the complexities of joint modeling methodologies. © 2011 by Hogrefe Publishing.

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