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Enhanced growth of neural networks on conductive cellulose-derived nanofibrous scaffolds

Artikel i vetenskaplig tidskrift
Författare Volodymyr Kuzmenko
Theodoros Kalogeropoulos
Johannes Thunberg
Sara Johannesson
Daniel Hägg
Peter Enoksson
Paul Gatenholm
Publicerad i Materials science & engineering. C, biomimetic materials, sensors and systems
Volym 58
Sidor 14-23
ISSN 0928-4931
Publiceringsår 2016
Publicerad vid
Sidor 14-23
Språk en
Ämnesord Electrospun cellulose; Conductive scaffolds; Cell attachment; Neural network
Ämneskategorier Cellbiologi, Ytbehandlingsteknik, Nanoteknik, Neurovetenskaper, Biomaterialvetenskap

Sammanfattning

The problemof recovery fromneurodegeneration needs new effective solutions. Tissue engineering is viewed as a prospective approach for solving this problemsince it can help to develop healthy neural tissue using supportive scaffolds. This study presents effective and sustainable tissue engineering methods for creating biomaterials from cellulose that can be used either as scaffolds for the growth of neural tissue in vitro or as drug screening models. To reach this goal, nanofibrous electrospun cellulose mats were made conductive via two different procedures: carbonization and addition of multi-walled carbon nanotubes. The resulting scaffolds were much more conductive than untreated cellulose material and were used to support growth and differentiation of SH-SY5Y neuroblastoma cells. The cells were evaluated by scanning electron microscopy and confocal microscopy methods over a period of 15 days at different time points. The results showed that the cellulose-derived conductive scaffolds can provide support for good cell attachment, growth and differentiation. The formation of a neural network occurred within 10 days of differentiation, which is a promising length of time for SH-SY5Y neuroblastoma cells.

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