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Early amplitude-integrated electroencephalography predicts brain injury and neurological outcome in very preterm infants

Artikel i vetenskaplig tidskrift
Författare J. Song
F. L. Xu
L. S. Wang
L. Gao
J. J. Guo
L. Xia
Y. H. Zhang
W. H. Zhou
Xiaoyang Wang
Changlian Zhu
Publicerad i Scientific Reports
Volym 5
Sidor Article nr. 13810
ISSN 2045-2322
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor Article nr. 13810
Språk en
Länkar dx.doi.org/10.1038/srep13810
Ämnesord intraventricular hemorrhage, premature-infants, systematic analysis, time trends, birth, maturation, aeeg, eeg, lesions, damage
Ämneskategorier Neurovetenskaper

Sammanfattning

Early amplitude-integrated electroencephalography (aEEG) has been widely used in term infants with brain injury to predict neurodevelopmental outcomes; however, the prognostic value of early aEEG in preterm infants is unclear. We evaluated how well early aEEG could predict brain damage and long-term neurodevelopmental outcomes in very preterm infants compared with brain imaging assessments. We found that severe aEEG abnormalities (p = 0.000) and aEEG total score < 5 (p = 0.006) within 72 h after birth were positively correlated with white-matter damage, but aEEG abnormalities were not associated with intracranial hemorrhage (p = 0.186). Severe abnormalities in aEEG recordings, head ultrasound, and cranial magnetic resonance imaging (MRI) were all positively correlated with poor outcome at 18 months corrected age. The predictive power of poor outcomes of the aEEG and MRI combination was the same as the aEEG, MRI, and head ultrasound combination with a sensitivity of 52.4%, specificity of 96.2%, positive predictive value of 78.6%, and negative predictive value of 88.4%. These results indicate that severely abnormal aEEG recordings within 72 h after birth can predict white-matter damage and long-term poor outcomes in very preterm infants. Thus aEEG can be used as an early marker to monitor very preterm infants.

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