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Serum visinin-like protein-1 in concussed professional ice hockey players

Artikel i vetenskaplig tidskrift
Författare Pashtun Shahim
Niklas Mattsson
E. M. Macy
D. L. Crimmins
J. H. Ladenson
Henrik Zetterberg
Kaj Blennow
Y. Tegner
Publicerad i Brain Injury
Volym 29
Nummer/häfte 7-8
Sidor 872-876
ISSN 0269-9052
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 872-876
Språk en
Länkar dx.doi.org/10.3109/02699052.2015.10...
Ämnesord Biomarker, brain injury, concussion, ice hockey, VILIP-1, TRAUMATIC BRAIN-INJURY, ALZHEIMER-DISEASE, INTERNATIONAL-CONFERENCE, CEREBROSPINAL-FLUID, BIOMARKERS, OVEREXPRESSION, STATEMENT, BLOOD, SPORT, Neurosciences, Rehabilitation
Ämneskategorier Klinisk medicin

Sammanfattning

Primary objective: Visinin-like protein-1 (VILIP-1) has shown potential utility as a biomarker for neuronal injury in cerebrospinal fluid. This study investigated serum VILIP-1 as a diagnostic and prognostic marker in sports-related concussion. Methods: This multi-centre prospective cohort study involved the 12 teams of the professional ice hockey league in Sweden. A total of 288 players consented to participate in the study. Thirty-five players sustained concussions, of whom 28 underwent repeated blood samplings at 1, 12, 36 and 144 hours after the trauma or when the player returned to play (7-90+ days). Main outcomes and results: The highest levels of VILIP-1 were measured 1 hour after concussion and the levels decreased during rehabilitation, reaching a minimum level at the 36-hour sampling. However, the levels of serum VILIP-1 at 1 hour after concussion were not significantly higher than pre-season baseline values. Serum levels of VILIP-1 1 hour post-concussion did not correlate with-the number of days for the concussion symptoms to resolve. Further, serum levels of VILIP-1 increased after a friendly game in players who were not concussed. Conclusions: These results provide evidence that serum VILIP-1 may not be a useful biomarker for diagnosis and prognosis of sports-related concussion.

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