Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Growth Hormone Treatment … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Growth Hormone Treatment Improves Cognitive Function in Short Children with Growth Hormone Deficiency

Artikel i vetenskaplig tidskrift
Författare John Chaplin
Berit Kriström
B. Jonsson
T. Tuvemo
Kerstin Albertsson-Wikland
Publicerad i Hormone Research in Paediatrics
Volym 83
Nummer/häfte 6
Sidor 390-399
ISSN 1663-2818
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 390-399
Språk en
Länkar dx.doi.org/10.1159/000375529
Ämnesord Cognition, IQ, Insulin-like growth factor I, Short stature, Fluid intelligence, Idiopathic short stature, FOR-GESTATIONAL-AGE, SHORT PREPUBERTAL CHILDREN, CENTRAL-NERVOUS-SYSTEM, FACTOR-I, GH DEFICIENCY, FLUID INTELLIGENCE, REFERENCE VALUES, OLDER, MEN, IGF-I, BRAIN, Endocrinology & Metabolism, Pediatrics
Ämneskategorier Pediatrik, Endokrinologi

Sammanfattning

Background/Aims: We investigated the association between cognition and growth hormone (GH) status and GH treatment in short prepubertal children with broadly ranging GH secretion. Methods: A total of 99 children (age 3-11 years), 41 with GH deficiency (GHD) and 58 with idiopathic short stature (ISS), were randomized to a fixed dose (43 mu g/kg/day) or a prediction model-guided individualized dose (17-100 mu g/kg/day) and followed up for 24 months. In a longitudinal and mixed within-and between-subjects study, we examined clinical effect size changes, measured by Cohen's d, in full-scale IQ (FSIQ) and secondary IQ indices. Results: Significant increases giving medium effect size in FSIQ (p = 0.001, Cohen's d = 0.63), performance IQ (p = 0.001, Cohen's d = 0.65) and processing speed (p = 0.005, Cohen's d = 0.71) were found in the GH-deficient group. In contrast, perceptual organization only increased in the ISS group (p = 0.001, Cohen's d = 0.53). Baseline IQ was normally distributed with small but significant differences between the groups: GH-deficient children had lower FSIQ (p = 0.042) and lower performance IQ (p = 0.021). Using multiple regression analysis, 40% of the variance in delta processing speed scores (0-24 months) was explained by GH(max) and IGF-I-SDS at baseline. Conclusion: IQ, specifically fluid intelligence, increased in the GH-deficient children. The pretreatment status of the GH/IGF-I axis was significantly predictive for these changes. (C) 2015 S. Karger AG, Basel

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?