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Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles

Artikel i vetenskaplig tidskrift
Författare Gunnel Hellgren
Eva Engström
L. E. Smith
Chatarina Löfqvist
Ann Hellström
Publicerad i Neonatology
Volym 108
Nummer/häfte 1
Sidor 16-22
ISSN 1661-7800
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 16-22
Språk en
Länkar dx.doi.org/10.1159/000381278
Ämnesord Prematurity, Apolipoproteins, Adipocytokines, Multiplex assay, DENSITY-LIPOPROTEIN CHOLESTEROL, UMBILICAL-CORD BLOOD, GESTATIONAL-AGE, GLOBAL LEVELS, BRAIN-INJURY, INFANTS, LEPTIN, GROWTH, ASSOCIATION, METABOLISM, Pediatrics
Ämneskategorier Klinisk medicin

Sammanfattning

Background: Critical metabolic changes preparing for ex utero life may occur at the fetal age of approximately 28-32 weeks, and preterm birth <28 weeks postmenstrual age (PMA) may affect these pathways. Children born <28 weeks often have poorer outcomes possibly due to a major shift in metabolism, including nutritional supply and a shift in lipid-transporting particles and lipid profile. This shift may occur in apolipoprotein and adipocytokine levels, which may influence metabolism. Objective: To determine whether there is a shift in apolipoprotein and adipocytokine levels in neonates born at a gestational age (GA) of 28 and 32 weeks, respectively. Methods: Blood samples from 47 infants (GA 32 weeks, n = 30 and GA 28 weeks, n = 17) were collected at birth and, in the GA28 group, also at PMA 32 weeks. Apolipoproteins A-1, A-2, B, C-2, C-3, and E were analyzed, as well as adiponectin and leptin levels. Results: Serum levels of apolipoproteins A-1, C-2, C-3, and E were lower at birth in the GA28 group compared to the GA32 group. Adiponectin and leptin levels were low at birth in the GA28 group. In the GA28 group 4 weeks after birth, leptin levels were still low, whereas adiponectin levels had increased to levels similar to those found at birth in the GA32 group. Apolipoprotein A-1, C-2, C-3, and E levels were negatively correlated with days receiving total parenteral nutrition. Conclusion: There are significant differences in apolipoprotein and adipocytokine levels, which can be associated with GA and birth weight. The impact of these changes on neonatal and future morbidity remains to be determined. (C) 2015 S. Karger AG, Basel

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