Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

New developments in goble… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

New developments in goblet cell mucus secretion and function

Forskningsöversiktsartikel
Författare George M. H. Birchenough
Malin E V Johansson
Jenny K Gustafsson
Joakim H. Bergström
Gunnar C. Hansson
Publicerad i Mucosal Immunology
Volym 8
Nummer/häfte 4
Sidor 712-719
ISSN 1933-0219
Publiceringsår 2015
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 712-719
Språk en
Länkar dx.doi.org/10.1038/mi.2015.32
Ämnesord INTESTINAL MUCUS, INTERLEUKIN-10-DEFICIENT MICE, ULCERATIVE-COLITIS, MUCOSAL IMMUNITY, CYSTIC-FIBROSIS, CFTR CHANNEL, HUMAN COLON, MUCIN, INFLAMMATION, BACTERIA, Immunology
Ämneskategorier Immunologi inom det medicinska området

Sammanfattning

Goblet cells and their main secretory product, mucus, have long been poorly appreciated; however, recent discoveries have changed this and placed these cells at the center stage of our understanding of mucosal biology and the immunology of the intestinal tract. The mucus system differs substantially between the small and large intestine, although it is built around MUC2 mucin polymers in both cases. Furthermore, that goblet cells and the regulation of their secretion also differ between these two parts of the intestine is of fundamental importance for a better understanding of mucosal immunology. There are several types of goblet cell that can be delineated based on their location and function. The surface colonic goblet cells secrete continuously to maintain the inner mucus layer, whereas goblet cells of the colonic and small intestinal crypts secrete upon stimulation, for example, after endocytosis or in response to acetyl choline. However, despite much progress in recent years, our understanding of goblet cell function and regulation is still in its infancy.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?