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CD244 is expressed on dendritic cells and regulates their functions

Artikel i vetenskaplig tidskrift
Författare A. M. Georgoudaki
S. Khodabandeh
S. Puiac
C. M. Persson
M. K. Larsson
M. Lind
O. Hammarfjord
T. H. Nabatti
R. P. A. Wallin
Ulf Yrlid
M. Rhen
V. Kumar
B. J. Chambers
Publicerad i Immunology and Cell Biology
Volym 93
Nummer/häfte 6
Sidor 581-590
ISSN 0818-9641
Publiceringsår 2015
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 581-590
Språk en
Länkar dx.doi.org/10.1038/icb.2014.124
Ämnesord COLONY-STIMULATING FACTOR, NATURAL-KILLER-CELLS, NK-CELLS, CUTTING EDGE, IMMUNE-RESPONSES, 2B4 CD244, 2B4/CD48 INTERACTIONS, MOLECULAR-BASIS, SLAM FAMILY, T-CELLS, Cell Biology, Immunology
Ämneskategorier Immunologi inom det medicinska området

Sammanfattning

Signaling lymphocytic activation molecule (SLAM) receptors have an important role in the development of immune responses because of their roles, for exampe, in NK cell cytotoxicity and cytokine production by NK, T cells and myeloid cells. The SLAM receptor CD244 (2B4, SLAMf4) is expressed on a variety of immune cell types but most of its functions have been examined on NK and T cells. In the present study, we investigated expression and function of CD244 in murine subsets of dendritic cells (DCs). We report that all subsets of murine DCs examined expressed CD244, although the expression levels of CD244 varied between subsets. Splenic and resident mesenteric lymph node (MLN) DCs from CD244(-/-) mice expressed lower levels of CD86 and MHC class II compared with wild-type mice. Upon Toll-like receptor (TLR) stimulation, no differences in surface expression of these molecules were observed between DCs from CD244(-/-) and wild-type mice. However, splenic DCs from CD244(-/-) mice upon stimulation with TLR binding ligands lipopolysaccharide (LPS) and CpG produced significantly higher levels of pro-inflammatory cytokines. In addition, DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.

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