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Evaluation of cationic micropeptides derived from the innate immune system as inhibitors of marine biofouling

Artikel i vetenskaplig tidskrift
Författare R. Trepos
Gunnar Cervin
C. Pile
Henrik Pavia
C. Hellio
J. Svenson
Publicerad i Biofouling
Volym 31
Nummer/häfte 4
Sidor 393-403
ISSN 0892-7014
Publiceringsår 2015
Publicerad vid Institutionen för biologi och miljövetenskap, Tjärnö marinbiologiska laboratorium
Sidor 393-403
Språk en
Länkar dx.doi.org/10.1080/08927014.2015.10...
Ämnesord antifouling, innate defence, nontoxic, peptides, amphiphilic, SYNTHETIC ANTIMICROBIAL PEPTIDOMIMETICS, BARNACLE BALANUS-IMPROVISUS, ANTIFOULING COMPOUNDS, ANTIBACTERIAL PEPTIDES, BOVINE LACTOFERRIN, RELEASE COATINGS, NATURAL-PRODUCTS, FOULING-RELEASE, ANALOGS, STABILITY, Biotechnology & Applied Microbiology, Marine & Freshwater Biology, XTER SC, 1993, BIOFOULING, V7, P97
Ämneskategorier Medicinsk bioteknologi

Sammanfattning

A series of 13 short synthetic amphiphilic cationic micropeptides, derived from the antimicrobial iron-binding innate defence protein lactoferrin, have been evaluated for their capacity to inhibit the marine fouling process. The whole biofouling process was studied and microfouling organisms such as marine bacteria and microalgae were included as well as the macrofouling barnacle Balanus improvisus. In total 19 different marine fouling organisms (18 microfoulers and one macrofouler) were included and both the adhesion and growth of the microfoulers were investigated. It was shown that the majority of the peptides inhibited barnacle cyprid settlement via a reversible nontoxic mechanism, with IC50 values as low as 0.5 mu g ml(-1). Six peptides inhibited adhesion and growth of microorganisms. Two of these were particularly active against the microfoulers with MIC-values ranging between 0.01 and 1 mu g ml(-1), which is comparable with the commercial reference antifoulant SeaNine.

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