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An attempt to estimate out-of-plane lung nodule elongation in tomosynthesis images

Paper i proceeding
Författare Artur Chodorowski
Jonathan Arvidsson
Christina Söderman
Angelica Svalkvist
Åse (Allansdotter) Johnsson
Magnus Båth
Publicerad i Medical Imaging 2015: Physics of Medical Imaging (SPIE Proceedings). Conference on Medical Imaging - Physics of Medical Imaging. February 22-25, 2015, Orlando, Florida, USA.
ISBN 978-1-62841-502-5
ISSN 0277-786X
Publiceringsår 2015
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för radiofysik
Institutionen för kliniska vetenskaper, Avdelningen för radiologi
Språk en
Länkar dx.doi.org/10.1117/12.2079901
https://gup.ub.gu.se/file/187425
Ämnesord chest tomosynthesis, pulmonary nodules, 3D reconstruction, filtered back projection, volumetry
Ämneskategorier Radiologi och bildbehandling

Sammanfattning

In chest tomosynthesis (TS) the most commonly used reconstruction methods are based on Filtered Back Projection (FBP) algorithms. Due to the limited angular range of x-ray projections, FBP reconstructed data is typically associated with a low spatial resolution in the out-of-plane dimension. Lung nodule measures that depend on depth information such as 3D shape and volume are therefore difficult to estimate. In this paper the relation between features from FBP reconstructed lung nodules and the true out-of-plane nodule elongation is investigated and a method for estimating the out-of-plane nodule elongation is proposed. In order to study these relations a number of steps that include simulation of spheroidal-shaped nodules, insertion into synthetic data volumes, construction of TS-projections and FBP-reconstruction were performed. In addition, the same procedure was used to simulate nodules and insert them into clinical chest TS projection data. The reconstructed nodule data was then investigated with respect to in-plane diameter, out-of-plane elongation, and attenuation coefficient. It was found that the voxel value in each nodule increased linearly with nodule elongation, for nodules with a constant attenuation coefficient. Similarly, the voxel value increased linearly with in-plane diameter. These observations indicate the possibility to predict the nodule elongation from the reconstructed voxel intensity values. Such a method would represent a quantitative approach to chest tomosynthesis that may be useful in future work on volume and growth rate estimation of lung nodules.

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