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Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Artikel i vetenskaplig tidskrift
Författare Fredrik Bäckhed
Josefine Roswall
Y. Q. Peng
Qing-Ping Feng
H. J. Jia
Petia Kovatcheva-Datchary
Y Liu
Y. Xia
H. L. Xie
H. Z. Zhong
Muhammad Tanweer Khan
J. F. Zhang
J. H. Li
L. Xiao
J. Al-Aama
D. Y. Zhang
Ying Shiuan Lee
D. Kotowska
C. Colding
Valentina Tremaroli
Y. Yin
Stefan Bergman
X. Xu
L. Madsen
K. Kristiansen
Jovanna Dahlgren
W. Jun
Publicerad i Cell Host & Microbe
Volym 17
Nummer/häfte 5
Sidor 690-703
ISSN 1931-3128
Publiceringsår 2015
Publicerad vid Wallenberglaboratoriet
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 690-703
Språk en
Länkar dx.doi.org/10.1016/j.chom.2015.04.0...
Ämnesord INTESTINAL MICROBIOTA, INFANT GUT, METAGENOME, BACTERIA, MELATONIN, PROTEINS, CHILDREN, NEWBORNS, CATALOG, DISEASE, Microbiology, Parasitology, Virology
Ämneskategorier Pediatrik

Sammanfattning

The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.

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