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The severity of inflammation at onset of ulcerative colitis is not associated with IBS-like symptoms during clinical remission

Artikel i vetenskaplig tidskrift
Författare Börje Jonefjäll
Magnus Simrén
Lena Öhman
A. Lasson
Jan Svedlund
Hans Strid
Publicerad i Journal of Crohn's & Colitis
Volym 9
Nummer/häfte 9
Sidor 776-783
ISSN 1873-9946
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 776-783
Språk en
Länkar dx.doi.org/10.1093/ecco-jcc/jjv107
Ämneskategorier Gastroenterologi

Sammanfattning

BACKGROUND AND AIMS: Symptoms compatible with Irritable bowel syndrome (IBS) are common in patients with ulcerative colitis (UC) in clinical remission. It has been suggested that these symptoms might arise due to post-inflammatory changes comparable with post-infectious IBS. The aim was to study factors at new onset of UC that predict development of IBS-like symptoms during clinical remission. METHODS: In total, 98 patients with new onset of UC were followed prospectively during three years with yearly follow up visits. Data from the first visit at the onset of UC were compared between the group of patients that fulfilled the criteria for IBS while in remission (UCR+IBS) during follow-up and the group that did not (UCR-IBS). RESULTS: Among the UC patients, 87 met the criteria for clinical remission, and 25 (29%) of these reported IBS-like symptoms in remission during follow-up. There was no difference in inflammatory disease activity at the initial flare or prevalence of previous IBS symptoms comparing UCR+IBS and UCR-IBS patients. The UCR+IBS patients reported more severe GI symptoms including abdominal pain during their primary flare. CONCLUSION: The severity and extension of inflammation at onset of UC do not seem to affect the development of IBS-like symptoms in UC patients during clinical remission. The high prevalence of IBS-like symptoms is not explained by pre-existing IBS. UCR+IBS patients reported more severe GI symptoms at disease onset, which might indicate a more sensitive GI tract in this category of patients.

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