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Microscopic study of dental hard tissues in primary teeth with Dentinogenesis Imperfecta Type II: Correlation of 3D imaging using X-ray microtomography and polarising microscopy

Artikel i vetenskaplig tidskrift
Författare G. R. Davis
J. M. Fearne
Nina Sabel
Jörgen G Norén
Publicerad i Archives of Oral Biology
Volym 60
Nummer/häfte 7
Sidor 1013-1020
ISSN 0003-9969
Publiceringsår 2015
Publicerad vid Institutionen för odontologi, sektion 3
Sidor 1013-1020
Språk en
Länkar dx.doi.org/10.1016/j.archoralbio.20...
Ämnesord Dentinogenesis Imperfecta, Micro-CT, Pulp obliteration, Pulpal capillaries, Polarising light microscopy, OSTEOGENESIS-IMPERFECTA, MINERAL CONCENTRATION, ENAMEL LESIONS, DSPP, GENE, DEFECTS, DYSPLASIA, ULTRASTRUCTURE, DIMENSIONS, DISORDERS, MUTATIONS, Dentistry, Oral Surgery & Medicine
Ämneskategorier Odontologi

Sammanfattning

Objectives: The aim of this study was to examine the histological appearance of dental hard tissues in primary teeth from children with DI using conventional polarised light microscopy and correlate that with 3D imaging using X-ray microtomograpy (XMT) to gain a further understanding of the dentine structure of teeth diagnosed with dentinogenesis imperfecta. Design: Undecalcified sections of primary teeth from patients diagnosed with Dentinogenesis Imperfecta Type II were examined using polarised light microscopy. XMT was employed for 3D-imaging and analysis of the dentine. Results: The polarised light microscopy and XMT revealed tubular structures in the dentine seen as vacuoles coinciding with the path of normal dentinal tubules but not continuous tubules. The size of the tubules was close to that of capillaries. The largest tubular structures had a direction corresponding to where the pulp tissue would have been located during primary dentine formation. The dysfunctional mineralisation of the dentine and obliteration of the pulp evidently leaves blood vessels in the dentine which have in the main been tied off and, in the undecalcified sections, appear as vacuoles. Conclusions: Although from radiographs, the pulp in teeth affected by Dentinogenesis Imperfect type II appears to be completely obliterated, a network of interconnected vessels may remain. The presence of large dentinal tubules and blood vessels, or the remnants of blood vessels, could provide a pathway for bacteria from the oral cavity. This might account for why some of these teeth develop periapical abscesses in spite of apparently having no pulp. (c) 2015 Elsevier Ltd. All rights reserved.

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