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Differential Impact of Neurofilament Light Subunit on Cognition and Functional Outcome in Memory Clinic Patients with and without Vascular Burden

Artikel i vetenskaplig tidskrift
Författare Sindre Rolstad
Anne Ingeborg Berg
Carl Eckerström
Boo Johansson
Anders Wallin
Publicerad i Journal of Alzheimers Disease
Volym 45
Nummer/häfte 3
Sidor 873-881
ISSN 1387-2877
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Psykologiska institutionen
Sidor 873-881
Språk en
Länkar dx.doi.org/10.3233/jad-142694
Ämnesord Amyloid-beta(1-42), cerebrospinal fluid, cognition, dementia, mild cognitive impairment, CEREBROSPINAL-FLUID BIOMARKERS, WHITE-MATTER CHANGES, ALZHEIMER-DISEASE, CSF BIOMARKERS, DIAGNOSTIC-CRITERIA, PROTEIN-LEVELS, DEMENTIA, IMPAIRMENT, DECLINE, PROFILES
Ämneskategorier Neurologi

Sammanfattning

The neurofilament light (NF-L) subunit is mainly expressed in large-caliber myelinated axons, and elevated concentrations in the cerebrospinal fluid (CSF) are correlated with damage to white matter and subcortical regions. Because the correlation between NF-L and cognition and functional impairment is largely unknown, we investigated associations in patients (n = 622) with (n = 199) and without (n = 423) vascular burden in subjective cognitive impairment (SCI, n = 168), mild cognitive impairment (MCI, n = 261), and dementia (n = 193). Patients were staged according to disease severity and the presence/absence of cerebrovascular disease. CSF amyloid-beta(1-42) (A beta(1-42))was included in all models due to its concomitant influence on vascular and primary etiology. Linear regression was used to assess associations between NF-L and A beta(1-42) and five cognitive domains of a comprehensive neuropsychological battery as well as with functional impairment using the Clinical Dementia Rating. Changes in these outcomes at the 2-year follow-up were also evaluated. In SCI and MCI patients with vascular burden, higher NF-L concentrations were associated with baseline cognitive performance (beta = -0.38 to -0.58) and executive decline (beta = -0.44). Lower A beta(1-42) levels were associated with worse cognitive performance in dementia (beta = 0.46 to 0.51). In MCI and dementia patients without vascular burden, higher NF-L (beta = -0.30 to -0.34) and lower A beta(1-42) concentrations (beta = 0.30) were associated with reduced cognitive performance. Higher NF-L concentrations (beta = -0.26) were associated with functional decline in patients with vascular burden. CSF NF-L is associated with cognition in patients with and without vascular etiology. These associations were greater in pre-dementia phases in those with vascular etiology and vice versa in those without vascular burden.

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