Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

A family history of Type … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress

Artikel i vetenskaplig tidskrift
Författare Sejla Brkic
Bo Söderpalm
Anna Söderpalm Gordh
Publicerad i Pharmacology Biochemistry and Behavior
Volym 130
Sidor 59-66
ISSN 0091-3057
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 59-66
Språk en
Länkar dx.doi.org/10.1016/j.pbb.2014.12.00...
Ämnesord Alcohol, Family history of alcoholism, Stress, TSST, High and low cortisol responders, PITUITARY-ADRENAL AXIS, ASSISTED SELF-INFUSION, PSYCHOSOCIAL STRESS, HPA-AXIS, PSYCHOLOGICAL STRESS, SALIVARY CORTISOL, VOLUNTARY ALCOHOL, HEALTHY-SUBJECTS, SOCIAL DRINKERS, RESPONSES, Behavioral Sciences, Neurosciences, Pharmacology & Pharmacy
Ämneskategorier Farmakologi, Neurovetenskaper

Sammanfattning

Background: The differentiation between high and low cortisol responders to stress is of interest in determining the risk factors which may, along with genetic vulnerability, influence alcohol intake. Study 1: Methods: Thirty-two healthy volunteers, family history positive to alcoholism (FHP, n = 16) and family history negative (FUN, n = 16) attended two laboratory sessions during which alcohol or placebo was offered. Results: There were no differences in consumption of alcohol or placebo between FHP and FHN subjects. Study 2: Methods: Fifty-eight healthy social drinkers, FHP (n = 27) and FUN (n = 31) attended two laboratory sessions. They were administered either alcohol or placebo in both sessions they attended. All subjects underwent either a stress task (the Trier Social Stress Test, TSST) or a stress-free period, at two separate occasions, before being offered beverage. After the salivary cortisol analysis, subjects in each group were divided into high (HCR) or low (LCR) cortisol responders. Results: After stress, subjects who were FHP-HCR consumed more alcohol than FHN-HCR. There were no differences in the placebo intake between FHP and FHN subjects regardless of their cortisol response. Conclusions: This result indicates that stress promotes alcohol consumption only in subjects with a family history of Type 1 alcoholism who show an increase in cortisol response to stress. This behaviour is similar to that previously observed in alcohol dependent individuals after stress and thus could represent an endophenotype posing a risk for future development of alcohol use disorders. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?