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Inflammatory cytokine release is affected by surface morphology and chemistry of titanium implants.

Artikel i vetenskaplig tidskrift
Författare Anna Karin Ostberg
Ulf Dahlgren
Young-Taeg Sul
Carina B. Johansson
Publicerad i Journal of materials science. Materials in medicine
Volym 26
Nummer/häfte 4
Sidor 5486
ISSN 1573-4838
Publiceringsår 2015
Publicerad vid Institutionen för odontologi
Institutionen för odontologi, sektion 2
Institutionen för odontologi, sektion 3
Sidor 5486
Språk en
Länkar dx.doi.org/10.1007/s10856-015-5486-...
Ämneskategorier Biologiska vetenskaper, Materialteknik, Nanoteknik

Sammanfattning

To investigate in vitro cellular cytokine expression in relation to commercially pure titanium discs, comparing a native surface to a fluorinated oxide nanotube surface. Control samples pure titanium discs with a homogenous wave of the margins and grooves and an often smeared-out surface structure. Test samples pure titanium discs with a fluorinated titanium oxide chemistry and surface morphology with nanopore/tube geometry characterized by ordered structures of nanotubes with a diameter of ≈120 nm, a spacing of ≈30 nm, and a wall thickness of ≈10 nm. Cross-section view showed vertically aligned nanotubes with similar lengths of ≈700 nm. Peripheral blood mononuclear leucocytes were cultured for 1, 3, and 6 days according to standard procedures. BioPlex Pro™ assays were used for analysis and detection of cytokines. Selected inflammatory cytokines are reported. A pronounced difference in production of the inflammatogenic cytokines was observed. Leucocytes exposed to control coins produced significantly more TNF-α, IL-1ß, and IL-6 than the test nanotube coins. The effect on the TH2 cytokine IL-4 was less pronounced at day 6 compared to days 1 and 3, and slightly higher expressed on the control coins. The morphology and surface chemistry of the titanium surface have a profound impact on basic cytokine production in vitro. Within the limitations of the present study, it seems that the fluorinated oxide nanotube surface results in a lower inflammatory response compared to a rather flat surface that seems to favour inflammation.

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