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Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates

Artikel i vetenskaplig tidskrift
Författare Axel Josefsson
Michael Fu
E. Bjornsson
M. Castedal
Evangelos Kalaitzakis
Publicerad i European Journal of Gastroenterology & Hepatology
Volym 27
Nummer/häfte 4
Sidor 393-398
ISSN 0954-691X
Publiceringsår 2015
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 393-398
Språk en
Länkar dx.doi.org/10.1097/meg.000000000000...
Ämnesord cirrhotic cardiomyopathy, fatigue, health-related quality of life, left ventricular diastolic dysfunction, VENTRICULAR DIASTOLIC DYSFUNCTION, PRIMARY BILIARY-CIRRHOSIS, HEART-FAILURE, NATRIURETIC PEPTIDE, ADIPONECTIN, DISEASE, FATIGUE, CARDIOMYOPATHY, ASSOCIATIONS, POPULATION
Ämneskategorier Klinisk medicin

Sammanfattning

Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor any other echocardiographic feature was found to be associated with any other SF-36 or Fatigue Impact Scale domain (P>0.05 for all). On linear regression analysis after adjustment for confounders, a prolonged QTc interval was found to be related to a lower SF-36 mental component summary score (beta = -9.7, P = 0.009) and increased physical fatigue (beta = 10.5, P= 0.004). Neither serum N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T, nor adiponectin levels were found to be related to QoL (P> 0.05 for all). Serum adiponectin levels did not differ among patients with versus those without echocardiographic cardiac alterations (P> 0.05 for all). Conclusion A prolonged QTc interval, but not any echocardiographic abnormalities or cardiac biomarkers, seems to be predictive of QoL in cirrhosis.

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