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Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study.

Artikel i vetenskaplig tidskrift
Författare V Chouraki
A Beiser
L Younkin
SR Preis
G Weinstein
O Hansson
Ingmar Skoog
JC Lambert
R Au
L Launer
PA Wolf
S Younkin
S Seshadri
Publicerad i Alzheimer's & Dementia
Volym 11
Nummer/häfte 3
Sidor 249–257.e1
ISSN 1552-5260
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 249–257.e1
Språk en
Länkar dx.doi.org/10.1016/j.jalz.2014.07.0...
Ämnesord Aβ peptides; Epidemiology; Framingham Heart Study; Incident Alzheimer's disease; Incident dementia; Meta-analysis; Plasma biomarker
Ämneskategorier Neurovetenskaper, Epidemiologi

Sammanfattning

BACKGROUND: Plasma amyloid-β (Aβ) peptide levels have been examined as a low-cost accessible marker for risk of incident Alzheimer's disease (AD) and dementia, but results have varied between studies. We reassessed these associations in one of the largest, prospective, community-based studies to date. METHODS: A total of 2189 dementia-free, Framingham Study participants aged >60 years (mean age, 72 ± 8 years; 56% women) had plasma Aβ1-42 and Aβ1-40 measured and were followed prospectively (mean, 7.6 ± 3.0 years) for dementia/AD. RESULTS: Increased plasma Aβ1-42 levels were associated with lower risk of dementia (Aβ1-42: hazard ratio [HR] = 0.80 [0.71‒0.90], P < .001; Aβ1-42-to-Aβ1-40 ratio: HR = 0.86 [0.76‒0.98], P = .027) and AD (Aβ1-42: HR = 0.79 [0.69‒0.90], P < .001; Aβ1-42-to-Aβ1-40 ratio: HR = 0.83 [0.72‒0.96], P = .012). CONCLUSION: Our results suggest that lower plasma Aβ levels are associated with risk of incident AD and dementia. They encourage further evaluation of plasma Aβ levels as a biomarker for risk of developing clinical AD and dementia. Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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