Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

BMP4 and BMP antagonists … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

BMP4 and BMP antagonists regulate human white and beige adipogenesis.

Artikel i vetenskaplig tidskrift
Författare Birgit Gustafson
Ann Hammarstedt
Shahram Hedjazifar
Jenny M Hoffmann
Per-Arne Svensson
Joseph Grimsby
Cristina Rondinone
Ulf Smith
Publicerad i Diabetes
Volym 64
Nummer/häfte 5
Sidor 1670-1681
ISSN 1939-327X
Publiceringsår 2015
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 1670-1681
Språk en
Länkar dx.doi.org/10.2337/db14-1127
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

The limited expandability of subcutaneous adipose tissue, due to reduced ability to recruit and differentiate new adipocytes, prevents its buffering effect in obesity and is characterized by expanded adipocytes (hypertrophic obesity). Bone morphogenetic protein-4 (BMP4) plays a key role in regulating adipogenic precursor cell commitment and differentiation. We found BMP4 to be induced and secreted by differentiated (pre)adipocytes and BMP4 protein was increased in large adipose cells. However, the precursor cells exhibited a resistance to BMP4 due to increased secretion of the BMP inhibitor Gremlin-1 (GREM1). GREM1 is secreted by (pre)adipocytes and is an inhibitor of both BMP4 and BMP7. BMP4 alone, and/or silencing GREM1, increased transcriptional activation of peroxisome proliferator-activated receptor-γ (PPARγ) and promoted the preadipocytes to assume an oxidative beige/brown adipose phenotype including markers of increased mitochondria and PGC1α. Driving white adipose differentiation inhibited the beige/brown markers suggesting the presence of multipotent adipogenic precursor cells. However, silencing GREM1 and/or adding BMP4 during white adipogenic differentiation re-activated beige/brown markers suggesting that increased BMP4 preferentially regulates the beige/brown phenotype. Thus BMP4, secreted by white adipose cells, is an integral feedback regulator of both white and beige adipogenic commitment and differentiation and resistance to BMP4 by GREM1 characterizes hypertrophic obesity.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?