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The specific glycosphingolipid composition of human ureteral epithelial cells.

Artikel i vetenskaplig tidskrift
Författare Michael Breimer
Gunnar C. Hansson
H Leffler
Publicerad i Journal of biochemistry
Volym 98
Nummer/häfte 5
Sidor 1169-80
ISSN 0021-924X
Publiceringsår 1985
Publicerad vid Medicinska institutionen
Sidor 1169-80
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Carbohydrates, analysis, Cholesterol, analysis, Chromatography, Thin Layer, Epithelial Cells, Epithelium, analysis, Fatty Acids, analysis, Glycosphingolipids, analysis, Humans, Kidney, analysis, Phospholipids, analysis, Ureter, analysis, cytology
Ämneskategorier Klinisk medicin

Sammanfattning

Total non-acid and acid glycolipid fractions were isolated from epithelial cell scrapings and the non-epithelial residue of a human upper ureter. The glycolipid fractions were structurally characterized as total mixtures by thin-layer chromatography, mass spectrometry, and proton NMR spectroscopy. Selected structural information was also obtained on binding of monoclonal antibodies and bacteria to the thin-layer chromatograms. The major epithelial cell glycolipids were Glc beta 1-1ceramide (75%), dihexosylceramide (10%) and NeuAcLacceramide (10%). In addition, 8 minor glycolipids belonging to the blood group P, Lewis and ABO systems were identified. The major glycolipids of the non-epithelial residues were mono- and dihexosylceramides together with globotriaosyl- and globotetraosylceramides. The epithelial mono- and diglycosylceramide compounds had an unusual ceramide composition with mainly C18 and C20 trihydroxy long chain bases in combination with C22-C24 hydroxy fatty acids in contrast to the non-epithelial glycolipids which contained mainly C18 dihydroxy long chain bases in combination with C16-C24 non-hydroxy fatty acids.

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