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Age-related differences in recommended anthropometric cut-off point validity to identify cardiovascular risk factors in ostensibly healthy women.

Artikel i vetenskaplig tidskrift
Författare Sreevidya Subramoney
Cecilia Björkelund
Xinxin Guo
Ingmar Skoog
Ingvar Bosaeus
Lauren Lissner
Publicerad i Scandinavian Journal of Public Health
Volym 42
Nummer/häfte 8
Sidor 827-33
ISSN 1403-4948
Publiceringsår 2014
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 827-33
Språk en
Länkar dx.doi.org/10.1177/1403494814550178
Ämnesord Anthropometric cut-off points; cardiovascular risk factors; dyslipidaemia; hypertension; public health; screening; sensitivity; specificity; total fat %; waist circumference
Ämneskategorier Hälsovetenskaper, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Sammanfattning

AIM: To investigate validity of widely recommended anthropometric and total fat percentage cut-off points in screening for cardiovascular risk factors in women of different ages. METHODS: A population-based sample of 1002 Swedish women aged 38, 50, 75 (younger, middle-aged and elderly, respectively) underwent anthropometry, health examinations and blood tests. Total fat was estimated (bioimpedance) in 670 women. Sensitivity, specificity of body mass index (BMI; ≥25 and ≥30), waist circumference (WC; ≥80 cm and ≥88 cm) and total fat percentage (TF; ≥35%) cut-off points for cardiovascular risk factors (dyslipidaemias, hypertension and hyperglycaemia) were calculated for each age. Cut-off points yielding high sensitivity together with modest specificity were considered valid. Women reporting hospital admission for cardiovascular disease were excluded. RESULTS: The sensitivity of WC ≥80 cm for one or more risk factors was ~60% in younger and middle-aged women, and 80% in elderly women. The specificity of WC ≥80 cm for one or more risk factors was 69%, 57% and 40% at the three ages (p < .05 for age trends). WC ≥80 cm yielded ~80% sensitivity for two or more risk factors across all ages. However, specificity decreased with increasing age (p < .0001), being 33% in elderly. WC ≥88 cm provided better specificity in elderly women. BMI and TF % cut-off points were not better than WC. CONCLUSIONS: VALIDITY OF RECOMMENDED ANTHROPOMETRIC CUT-OFF POINTS IN SCREENING ASYMPTOMATIC WOMEN VARIES WITH AGE IN YOUNGER AND MIDDLE-AGE, WC ≥80 CM YIELDED HIGH SENSITIVITY AND MODEST SPECIFICITY FOR TWO OR MORE RISK FACTORS, HOWEVER, SENSITIVITY FOR ONE OR MORE RISK FACTOR WAS LESS THAN OPTIMAL WC ≥88 CM SHOWED BETTER VALIDITY THAN WC ≥80 CM IN ELDERLY OUR RESULTS SUPPORT AGE-SPECIFIC SCREENING CUT-OFF POINTS FOR WOMEN:

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