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Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory.

Artikel i vetenskaplig tidskrift
Författare César Diaz-Garcia
Liza Johannesson
Linus Ruijin Shao
Håkan Billig
Mats Brännström
Publicerad i Fertility and sterility
Volym 102
Nummer/häfte 6
Sidor 1545-1552.e1
ISSN 1556-5653
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Sidor 1545-1552.e1
Språk en
Länkar dx.doi.org/10.1016/j.fertnstert.201...
Ämnesord Rat; uterus; transplantation; allogeneic; immunosuppression; pregnancy; offspring
Ämneskategorier Reproduktionsmedicin och gynekologi

Sammanfattning

Objective To investigate whether allogeneic uterine grafts in a rat model, with tacrolimus immunosuppression, can harbor pregnancies that result in offspring with normal postnatal growth. Design Experimental animal study. Setting University hospital. Animal(s) Lewis rats as uterus donors and Piebald-Virol-Glaxo rats as recipients. Intervention(s) Animals were allocated to one of the following three groups: allogeneic uterus transplantation with end-to-side anastomosis to the external iliac vessels and immunosuppression with tacrolimus (UT+Tac; n = 10); sham surgery and immunosuppression with tacrolimus (Sham+Tac; n = 10); or sham surgery (Sham; n = 10). The rats were subsequently introduced to male rats with proven fertility and in the event of resulting pregnancy cesarean sections were performed on day 22 of pregnancy. Main Outcome Measure(s) Graft viability, fertility rate, perinatal death, birth weight, postnatal birth trajectory. Result(s) Pregnancy rate was higher in the control groups (70% Sham and 80% Sham+Tac) than in the transplanted group (50% UT+Tac), although these differences did not reach the significance threshold. There were no differences between groups regarding number of living pups or neonatal deaths. Pups born from UT+Tac mothers had birth weights similar to external control animals from our breeding colony (BC): UT+Tac males 6.2 ± 0.2 g, UT+Tac females 5.5 ± 0.6 g, BC males 5.8 ± 0.2 g, BC females 5.2 ± 0.3 g; n.s. Evaluation of uteri and placentas of pregnant animals revealed a somewhat reduced vascular density in both tissues in the UT+Tac group, and that was not seen in the Sham+Tac group. Conclusion(s) Allogeneic uterus transplantation and immunosuppression with tacrolimus is compatible with normal pregnancy and perinatal outcome in a rat model.

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