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Mucus Layers in Inflammatory Bowel Disease

Artikel i vetenskaplig tidskrift
Författare Malin E V Johansson
Publicerad i Inflammatory Bowel Diseases
Volym 20
Nummer/häfte 11
Sidor 2124-2131
ISSN 1078-0998
Publiceringsår 2014
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 2124-2131
Språk en
Länkar dx.doi.org/10.1097/mib.000000000000...
Ämnesord mucus, mucin, MUC2, inflammatory bowel disease, ulcerative colitis, Crohn's disease, intestinal, GEL-FORMING MUCINS, SMALL-INTESTINE, ULCERATIVE-COLITIS, GOBLET CELLS, O-GLYCOSYLATION, MOUSE STOMACH, INCREASED SUSCEPTIBILITY, ENDOPLASMIC-RETICULUM, COMMENSAL BACTERIA, COLORECTAL-CANCER, Gastroenterology & Hepatology
Ämneskategorier Gastroenterologi

Sammanfattning

The intestinal epithelium is covered with mucus with the main structural building block being the densely O-glycosylated MUC2 mucin. The intestinal epithelium is exposed to ingested material, our digestive machinery, and large amounts of microorganisms. Mucus is the first line of defense and aids to limit exposure to all these threats to the epithelium. In the small intestine, mucus acts as a matrix, which contains antimicrobial products, such as defensins and immunoglobulin A that limit epithelial exposure to the luminal bacteria. In the colon, the stratified inner mucus layer acts as a physical barrier excluding bacteria from the epithelium. Bacterial penetration of this normally restricted zone is observed in many colitis models and also in patients with ulcerative colitis. Mucus defects that allow bacteria to reach the epithelium and to stimulate an immune system response can lead to the development of intestinal inflammation. The current state of our knowledge concerning the function of the mucus layers and the main mucin component, MUC2, in inflammatory bowel disease is described in this review.

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