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Weight at first detection of retinopathy of prematurity predicts disease severity

Artikel i vetenskaplig tidskrift
Författare Pia Lundgren
Åse Wilde
Chatarina Löfqvist
L. E. H. Smith
Anna-Lena Hård
Ann Hellström
Publicerad i British Journal of Ophthalmology
Volym 98
Nummer/häfte 11
Sidor 1565-1569
ISSN 0007-1161
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 1565-1569
Språk en
Länkar dx.doi.org/10.1136/bjophthalmol-201...
Ämnesord LOW-BIRTH-WEIGHT, GROWTH-FACTOR-I, LONGITUDINAL POSTNATAL WEIGHT, 27, WEEKS GESTATION, PRETERM INFANTS, RISK, GAIN, VALIDATION, SWEDEN, BABIES, Ophthalmology
Ämneskategorier Oftalmologi

Sammanfattning

Objective To investigate whether postnatal weight at first detection of retinopathy of prematurity (ROP) can predict preterm infants who will develop severe ROP warranting treatment. Design This modern, population-based cohort included 147 infants born at gestational age (GA) < 32 weeks in the Gothenburg region during 2011-2012 and screened for ROP at Sahlgrenska University hospital. GA, birth weight (BW), and weekly postnatal weight from birth until postmenstrual age (PMA) 40 weeks data were retrospectively retrieved. Birth weight SD scores (BWSDS) were calculated. ROP data, including first detected ROP stage, maximal ROP stage, ROP treatment, and PMA at first detected sign of ROP were also retrieved. Weight SDS (WSDS) at first ROP detection was calculated. Results Stepwise multivariate logistic regression analysis revealed that the best fit-model of risk factors for developing severe ROP warranting treatment included; GA (OR= 0.28, CI 95% 0.12 to 0.66, p<0.01) and WSDS at first ROP detection (OR= 0.22, CI 95% 0.05 to 0.89, p<0.05). Conclusions Low weight and low WSDS at first ROP detection can be useful predictors for ROP warranting treatment.

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