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Genetic Variants of GSK3B are Associated with Biomarkers for Alzheimer's Disease and Cognitive Function

Artikel i vetenskaplig tidskrift
Författare Petronella Kettunen
Susanna Larsson
Sandra Holmgren
Sandra Olsson
Lennart Minthon
Henrik Zetterberg
Kaj Blennow
Staffan Nilsson
Annica Sjölander
Publicerad i Journal of Alzheimer's Disease
Volym 44
Nummer/häfte 4
Sidor 1313-1322
ISSN 1387-2877
Publiceringsår 2015
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för matematiska vetenskaper, matematisk statistik
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 1313-1322
Språk en
Länkar dx.doi.org/10.3233/JAD-142025
Ämnesord Alzheimer's disease; amyloid-beta peptide; association; biomarker; cerebrospinal fluid; gene; glycogen synthase kinase 3 beta; Mini-Mental State Examination; single nucleotide polymorphism; tau
Ämneskategorier Neurokemi

Sammanfattning

Background: Glycogen synthase kinase 3 beta (GSK3B) is the major kinase phosphorylating tau protein. Hyperphosphorylated tau is one of the hallmarks of Alzheimer's disease (AD). Despite extensive research, the role of GSK3B in AD pathogenesis is not fully understood.

Objective: To evaluate possible associations between gene variants of GSK3B and risk of AD. Methods: Twelve GSK3B tag single-nucleotide polymorphisms (SNPs), together with the previously AD-associated rs334558, were analyzed in 583 AD patients and 673 controls. Analyses on single marker and haplotype levels were done to relate to risk of AD, Mini-Mental State Examination (MMSE) scores, and cerebrospinal fluid (CSF) biomarker levels of total tau (T-tau), hyperphosphorylated tau (P-tau(181)), and amyloid-beta (A beta(42)).

Results: After correction for multiple testing, we found a number of associations of gene variants with CSF biomarker levels and cognitive function in the AD patients. Firstly, rs334558 was associated with elevated T-tau levels (p(c) = 0.04). Next, rs1154597 showed association with reducedA beta(42) levels (pc = 0.007). Lastly, rs3107669was associated with lower MMSE scores (p(c) = 0.03). In addition, one more SNP was nominally significantly associated with reduced A beta(42) levels and another was associated with reduced MMSE.

Conclusion: We found GSK3B gene variants associated with cognitive function and CSF biomarkers T-tau and A beta(42). To our knowledge, this is the first time GSK3B has been associated with cognitive function or CSF biomarkers reflecting neuronal degeneration (T-tau) and brain amyloid load (A beta(42)). The regulation of GSK3B needs to be investigated further, to fully understand how these GSK3B gene variants are involved in AD pathogenesis.

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