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The Bromotyrosine derivative Ianthelline isolated from the arctic marine sponge Stryphnus fortis inhibits marine micro- and macrobiofouling

Artikel i vetenskaplig tidskrift
Författare Kine Œ Hanssen
Gunnar Cervin
Rozenn Trepos
Julie Petitbois
Tor Haug
Espen Hansen
Jeanette H. Andersen
Henrik Pavia
Claire Hellio
Johan Svenson
Publicerad i Marine Biotechnology
Volym 16
Nummer/häfte 6
Sidor 684-694
ISSN 1436-2228
Publiceringsår 2014
Publicerad vid Institutionen för biologi och miljövetenskap, Tjärnö marinbiologiska laboratorium
Centrum för marin kemisk ekologi
Sidor 684-694
Språk en
Länkar link.springer.com/article/10.1007/s...
Ämnesord Antifouling, Bromotyrosine, Ianthelline, Marine natural product, Sponge metabolite
Ämneskategorier Marin ekologi, Bioorganisk kemi

Sammanfattning

The inhibition of marine biofouling by the bromotyrosine derivative ianthelline, isolated from the Arctic marine sponge Stryphnus fortis, is described. All major stages of the fouling process are investigated. The effect of ianthelline on adhesion and growth of marine bacteria and microalgae is tested to investigate its influence on the initial microfouling process comparing with the known marine antifoulant barettin as a reference. Macrofouling is studied via barnacle (Balanus improvisus) settlement assays and blue mussel (Mytilus edulis) phenoloxidase inhibition. Ianthelline is shown to inhibit both marine micro- and macrofoulers with a pronounced effect on marine bacteria (minimum inhibitory concentration (MIC) values 0.1–10 μg/mL) and barnacle larval settlement (IC50 = 3.0 μg/mL). Moderate effects are recorded on M. edulis (IC50 = 45.2 μg/mL) and microalgae, where growth is more affected than surface adhesion. The effect of ianthelline is also investigated against human pathogenic bacteria. Ianthelline displayed low micromolar MIC values against several bacterial strains, both Gram positive and Gram negative, down to 2.5 μg/mL. In summary, the effect of ianthelline on 20 different representative marine antifouling organisms and seven human pathogenic bacterial strains is presented.

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