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Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3.

Artikel i vetenskaplig tidskrift
Författare Sarah J Malmquist
Alexandra Abramsson
Hillary F McGraw
Tor H Linbo
David W Raible
Publicerad i Development (Cambridge, England)
Volym 140
Nummer/häfte 19
Sidor 3986-96
ISSN 1477-9129
Publiceringsår 2013
Publicerad vid
Sidor 3986-96
Språk en
Ämnesord Animals, Ganglia, Spinal, cytology, metabolism, Genes, erbB, genetics, physiology, Intracellular Signaling Peptides and Proteins, genetics, metabolism, Neural Crest, cytology, metabolism, Neurogenesis, genetics, physiology, Signal Transduction, genetics, physiology, Zebrafish, Zebrafish Proteins, genetics, metabolism
Ämneskategorier Neurovetenskaper

Sammanfattning

The multipotent cells of the vertebrate neural crest (NC) arise at the dorsal aspect of the neural tube, then migrate throughout the developing embryo and differentiate into diverse cell types, including the sensory neurons and glia of the dorsal root ganglia (DRG). As multiple cell types are derived from this lineage, it is ideal for examining mechanisms of fate restriction during development. We have isolated a mutant, ouchless, that specifically fails to develop DRG neurons, although other NC derivatives develop normally. This mutation affects the expression of Sorbs3, a scaffold protein known to interact with proteins involved in focal adhesions and several signaling pathways. ouchless mutants share some phenotypic similarities with mutants in ErbB receptors, EGFR homologs that are implicated in diverse developmental processes and associated with several cancers; and ouchless interacts genetically with an allele of erbb3 in DRG neurogenesis. However, the defect in ouchless DRG neurogenesis is distinct from ErbB loss of function in that it is not associated with a loss of glia. Both ouchless and neurogenin1 heterozygous fish are sensitized to the effects of ErbB chemical inhibitors, which block the development of DRG in a dose-dependent manner. Inhibitors of MEK show similar effects on DRG neurogenesis. We propose a model in which Sorbs3 helps to integrate ErbB signals to promote DRG neurogenesis through the activation of MAPK and upregulation of neurogenin1.

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