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Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study.

Artikel i vetenskaplig tidskrift
Författare Sebastian Lundström
Abraham Reichenberg
Jonas Melke
Maria Råstam
Nora Kerekes
Paul Lichtenstein
Christopher Gillberg
Henrik Anckarsäter
Publicerad i Journal of child psychology and psychiatry, and allied disciplines
Volym 56
Nummer/häfte 6
Sidor 702–710
ISSN 1469-7610
Publiceringsår 2015
Publicerad vid Gillbergcentrum
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Centrum för etik, juridik och mental hälsa
Sidor 702–710
Språk en
Länkar dx.doi.org/10.1111/jcpp.12329
Ämneskategorier Barn- och ungdomspsykiatri

Sammanfattning

BACKGROUND: Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. METHODS: Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. RESULTS: Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The 'healthy co-twin' in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). CONCLUSIONS: Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically.

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