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Faecal analysis and plasma complement factor 3c levels at admission for an acute attack of ulcerative colitis are predictive of the need for colectomy

Artikel i vetenskaplig tidskrift
Författare Maria Pagoldh
Stefan Lange
Eva Jennische
S. Almer
E. A. Bostrom
Anders Eriksson
Publicerad i European Journal of Gastroenterology and Hepathology
Volym 26
Nummer/häfte 3
Sidor 295-300
ISSN 0954-691X
Publiceringsår 2014
Publicerad vid Institutionen för biomedicin
Sidor 295-300
Språk en
Länkar dx.doi.org/10.1097/meg.000000000000...
Ämnesord cytokines, inflammation, predictive marker
Ämneskategorier Gastroenterologi

Sammanfattning

BackgroundUlcerative colitis is a chronic inflammation limited to the large bowel. Early identification of reliable predictive markers addressing the risk of need for colectomy in a severe attack of ulcerative colitis is of crucial importance.ObjectiveTo evaluate faecal characteristics and peripheral blood tests as predictive markers for subsequent risk of colectomy in a severe attack of ulcerative colitis.MethodsThis was an observational study. Samples were collected in a cohort of 18 patients with a severe attack of ulcerative colitis. A panel of selected variables was evaluated (faecal characteristics, peripheral blood samples including complement factor 3c, circulating cytokines and antisecretory factor) for ability to predict colectomy. The patients were observed for up to 58 months (median 37.5, range 0.5-58 months) and allocated to one of two groups depending on the clinical outcome on the basis of the need for colectomy.ResultsSeven patients underwent colectomy. The present study showed a positive correlation between increased bowel movements (P=0.01), faecal weight/bowel movement (P=0.03) and complement factor 3c levels (P=0.01) and a need for later colectomy. None of the other laboratory markers investigated were shown to be predictive of risk for later colectomy.ConclusionEarly faecal analysis and measurement of complement factor 3c may be useful as predictive markers of the need for colectomy related to a severe attack of ulcerative colitis.

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