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Rodent Models of Polycystic Ovary Syndrome: Phenotypic Presentation, Pathophysiology, and the Effects of Different Interventions

Artikel i vetenskaplig tidskrift
Författare Manuel Maliqueo
Anna Benrick
Elisabet Stener-Victorin
Publicerad i Seminars in Reproductive Medicine
Volym 32
Nummer/häfte 3
Sidor 183-193
ISSN 1526-8004
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 183-193
Språk en
Länkar dx.doi.org/10.1055/s-0034-1371090
Ämnesord rodent models, PCOS, treatment, phenotype, NERVE GROWTH-FACTOR, LOW-FREQUENCY ELECTROACUPUNCTURE, VALERATE-TREATED, RAT, FEMALE RATS, ESTRADIOL VALERATE, INSULIN SENSITIVITY, ADIPOSE-TISSUE, SYMPATHETIC INNERVATION, GENE-EXPRESSION, WOMENS HEALTH
Ämneskategorier Fysiologi

Sammanfattning

This review focuses on rodent models exposed to sex steroids prepubertally and describes their phenotypes and pathophysiology with specific focus on the estradiol valerate-, dihydrotestosterone-, and letrozole-induced rat polycystic ovary syndrome (PCOS) models. Phenotypic presentations are compared among models as a function of the timing and dose of the exposure. Furthermore, the use of these models to study the possible effects and mechanisms of different treatment modalities relevant for women with PCOS will be discussed. Importantly, we do not claim to review all available rodent models of PCOS. Despite the variety of rodent PCOS models currently available, there is no "gold standard" that mimics the complete range of abnormalities observed in women with PCOS. In this regard, it is important to select the most suitable model for the pathophysiological experiment to be performed or the treatment strategy to be tested. Important variables to take into consideration are dose, route of administration, timing and duration of exposure, and the relevance of the abnormalities of the reproductive and metabolic axes in the rodent model to those observed in human PCOS.

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