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Comparison of Body Surface Area versus Weight-Based Growth Hormone Dosing for Girls with Turner Syndrome.

Artikel i vetenskaplig tidskrift
Författare Lenneke Schrier
Marieke L de Kam
Rachel McKinnon
Amalina Che Bakri
Wilma Oostdijk
Theo C J Sas
Leonie A Menke
Barto J Otten
Sabine M P F de Muinck Keizer-Schrama
Berit Kriström
Carina Ankarberg-Lindgren
Jacobus Burggraaf
Kerstin Albertsson-Wikland
Jan M Wit
Publicerad i Hormone Research in Paediatrics
Volym 81
Nummer/häfte 5
Sidor 319-330
ISSN 1663-2818
Publiceringsår 2014
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 319-330
Språk en
Länkar dx.doi.org/10.1159/000357844
Ämnesord Turner syndrome; Growth hormone therapy; Body surface area; Body weight; Cost-effectiveness; Adult height
Ämneskategorier Pediatrik

Sammanfattning

Background/Aims: Growth Hormone (GH) dosage in childhood is adjusted for body size, but there is no consensus whether body weight (BW) or body surface area (BSA) should be used. We aimed at comparing the biological effect and cost-effectiveness of GH treatment dosed per m(2) BSA in comparison with dosing per kg BW in girls with Turner syndrome (TS). Methods: Serum IGF-I, GH dose, and adult height gain (AHG) from girls participating in two Dutch and five Swedish studies on the efficacy of GH were analyzed, and the cumulative GH dose and costs were calculated for both dose adjustment methods. Additional medication included estrogens (if no spontaneous puberty occurred) and oxandrolone in some studies. Results: At each GH dose, the serum IGF-I standard deviation score remained stable over time after an initial increase after the start of treatment. On a high dose (at 1 m(2) equivalent to 0.056-0.067 mg/kg/day), AHG was at least equal on GH dosed per m(2) BSA compared with dosing per kg BW. The cumulative dose and cost were significantly lower if the GH dose was adjusted for m(2) BSA. Conclusion: Dosing GH per m(2) BSA is at least as efficacious as dosing per kg BW, and is more cost-effective. © 2014 S. Karger AG, Basel.

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