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Associations between oxytocin-related genes and autistic-like traits.

Artikel i vetenskaplig tidskrift
Författare Daniel Hovey
Anna Zettergren
Lina Jonsson
Jonas Melke
Henrik Anckarsäter
Paul Lichtenstein
Lars Westberg
Publicerad i Social Neuroscience
Volym 9
Nummer/häfte 4
Sidor 378-386
ISSN 1747-0919
Publiceringsår 2014
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 378-386
Språk en
Länkar dx.doi.org/10.1080/17470919.2014.89...
Ämnesord Autism; Oxytocin; ARNT2; SIM1; CD38
Ämneskategorier Neurovetenskap

Sammanfattning

Abstract Oxytocin has repeatedly been shown to influence human behavior in social contexts; also, a relationship between oxytocin and the pathophysiology of autism spectrum disorder (ASD) has been suggested. In the present study, we investigated single-nucleotide polymorphisms (SNPs) in the oxytocin gene (OXT) and the genes for single-minded 1 (SIM1), aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) and cluster of differentiation 38 (CD38) in a population of 1771 children from the Child and Adolescent Twin Study in Sweden (CATSS). Statistical analyses were performed to investigate any association between SNPs and autistic-like traits (ALTs), measured through ASD scores in the Autism-Tics, ADHD and other Co-morbidities inventory. Firstly, we found a statistically significant association between the SIM1 SNP rs3734354 (Pro352Thr) and scores for language impairment (p = .0004), but due to low statistical power this should be interpreted cautiously. Furthermore, nominal associations were found between ASD scores and SNPs in OXT, ARNT2 and CD38. In summary, the present study lends support to the hypothesis that oxytocin and oxytocin neuron development may have an influence on the development of ALTs and suggests a new candidate gene in the search for the pathophysiology of ASD.

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