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The effect of amphetamine and L-dopa on tetrabenazine-induced suppression of intracranial self-stimulation in the rat.

Artikel i vetenskaplig tidskrift
Författare Sven G. Carlsson
Sven Ahlenius
Publicerad i Scandinavian journal of psychology
Volym 18
Nummer/häfte 2
Sidor 157-60
ISSN 0036-5564
Publiceringsår 1977
Publicerad vid Psykologiska institutionen
Sidor 157-60
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Amphetamine, administration & dosage, pharmacology, Animals, Depression, Chemical, Dose-Response Relationship, Drug, Humans, Injections, Intraperitoneal, Levodopa, administration & dosage, pharmacology, Male, Rats, Self Stimulation, drug effects, Tetrabenazine, pharmacology
Ämneskategorier Psykologi

Sammanfattning

The administration of d-amphetamine sulphate resulted in a restoration of intracranial self-stimulation (ICSS) suppressed by tetrabenazine (TBZ). A dose-dependent increase in the rate of ICSS was seen after L-dopa in animals pretreated with TBZ. d-Amhetamine is believed to act by facilitating the nerve-impulse induced release of central catecholamines (CA) whereas the blockage of the granular uptake-storage mechanism by TBZ will prevent the storage of CA formed from the administrated L-dopa and thereby interfere with their release by nerve-impulses. Thus, in the latter case, an activation of central CA receptors in all probability will be due to a dose-dependent diffusion of CA from nerve terminals. It is suggested that the failure to completely antagonize the TBZ-induced suppression of behaviour by L-dopa is due to the fact that a direct activation, independent of the nerve-impulse flow, of central CA receptors easily results in an overstimulation and a reduced specificity in behaviour.

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